77 articles - From Friday Nov 24 2023 to Friday Dec 01 2023
Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…
| Clin Gastroenterol Hepatol |
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AGA Clinical Practice Update on Appropriate and Tailored Polypectomy: Expert Review. BEST PRACTICE ADVICE 11: Refer patients with nonpedunculated polyps with clear evidence of submucosally invasive cancer for surgical evaluation. BEST PRACTICE ADVICE 12: Understand the endoscopy suite's electrosurgical generator settings appropriate for polypectomy or postpolypectomy thermal techniques. |
| J Hepatol |
Improved assessment of donor liver steatosis using Banff consensus recommendations and deep learning algorithms. Our findings support the use of Banff recommendations in daily practice and highlight the need for a granular analysis of their effect on liver transplantation outcomes. Impact and implications • We developed and validated the first automated deep-learning algorithms for steatosis standardized assessment based on the Banff Liver Working Group consensus recommendations. • Our algorithm provides an unbiased automated evaluation of steatosis, which will lay the groundwork for granular analysis of steatosis's short- and long-term effects on organ viability to identify clinically relevant steatosis cut-off for donor organ acceptance. • Implementing our algorithm in daily clinical practice will allow a more efficient and safe allocation of donor organs, aiming at improving the post-transplant outcomes of patients. |
meta-analyses and systematic reviews
| Am J Gastroenterol |
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Dye Chromoendoscopy Outperforms High-Definition White Light Endoscopy in Dysplasia Detection for IBD Patients: An Updated Meta-analysis of Randomized Controlled Trials. Our updated meta-analysis supports DCE as a superior strategy in overall dysplasia detection in IBD, even with HD scopes. When expertise is available, DCE should be considered for surveillance colonoscopy in high-risk IBD patients, with the acknowledgment that virtual chromoendoscopy shows equivalence in recent studies. Further multicenter trials with multiple endoscopists with varying expertise levels and longer-term outcome data showing a reduction in cancer or cancer-related death are needed. |
| Endosc Int Open |
Colorectal endoscopic submucosal dissection in the West: A systematic review and meta-analysis. The effectiveness of colorectal ESD for large colorectal polyps and early colorectal cancers is improving in Western countries, and recent resection rates are comparable to that seen in Asia. Colorectal perforation is still observed in about 5% of ESD; however, < 2% of patients need emergency surgery for AEs. |
RCT, clinical trials, retrospective studies, etc…
| Aliment Pharmacol Ther |
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Clinical trial: Clinical and endoscopic outcomes with ustekinumab in patients with Crohn's disease: Results from the long-term extension period of STARDUST. STARDUST LTE is the first interventional ustekinumab efficacy study to show a favourable benefit-risk profile with preservation of clinical and endoscopic outcomes through Week 104 using flexible, algorithm-driven dose adjustment including de-escalation. |
Efficacy and safety of upadacitinib for 16-week extended induction and 52-week maintenance therapy in patients with moderately to severely active ulcerative colitis. Patients without clinical response after 8 weeks' upadacitinib 45 mg induction therapy, may benefit from an additional 8 weeks of therapy. Clinical trial registration |
Long-term effectiveness and acceptability of switching from intravenous to subcutaneous infliximab in patients with inflammatory bowel disease treated with intensified doses: The REMSWITCH-LT study. Switching from IV to SC infliximab 120 mg every other week is safe and well accepted leading to low long-term risk of relapse. Tight monitoring and dose escalation should be recommended for patients receiving 10 mg/kg/6 weeks and 4 weeks, respectively. |
Longitudinal changes in renal function in patients with chronic hepatitis B on antiviral treatment. NUC-treated patients, especially those on TDF, faced a higher CKD progression risk than untreated patients. Entecavir- and TAF-treated patients had comparable CKD progression risks to untreated patients. No difference was observed between entecavir and TAF in the risk of CKD progression. |
| Am J Gastroenterol |
Psychiatric and educational aspects of familial adenomatous polyposis - a nationwide Danish cohort study with matched non-exposed individuals. Compared to non-exposed individuals, FAP patients had significantly less education and an increased risk of developing mood and behavioural disorders, with an increased likelihood of needing antidepressants and antipsychotics. |
| Clin Gastroenterol Hepatol |
Chronic Liver Disease and Cirrhosis Mortality Rates are Disproportionately Increasing in Younger Women in the US between 2000-2020. Mortality rates due to CLD and cirrhosis in the U.S. are increasing disproportionately in younger women. This finding was driven by higher rates in Non-Hispanic White and Hispanic individuals, with variation between U.S. states. Future studies are warranted to identify the reasons for these trends with the ultimate goal of improving outcomes. |
Prolonged gastrointestinal manifestations after recovery from COVID-19. In this follow-up survey of patients 12-18 months after hospitalization with COVID-19, there was a high prevalence of DGBIs and persistent GI symptoms. Prolonged gastrointestinal manifestations were associated with the severity of GI symptoms during hospitalization and with the degree of psychological trauma related to the illness experience. |
| Endosc Int Open |
Duodenal neuroendocrine tumors: Short-term outcomes of endoscopic submucosal dissection performed in the Western setting. In experienced hands, ESD for D-NETs can achieve a 100% en bloc resection rate. There were no cases of local recurrence or distant metastatic spread, indicating that ESD may be a viable option for patients with D-NETs 10 to 15 mm that are not surgical candidates. |
Pilot study of an endoluminal-suturing device as a treatment for patients with gastroesophageal reflux disease. Endoscopic full-thickness suturing of the esophagogastric junction with the Endomina suturing platform is feasible, allowing persistence of two-thirds of the plications, with promising results for decreasing reflux and improving GERD symptoms. |
Potential role of a novel endoscopic retrieval bag for large colorectal resected specimen: a proof-of-concept study. The median (interquartile range) retrieval time was 4 (4-8) minutes, and no apparent adverse events were observed. The novel Endo Carry Large Type device can accomplish colorectal specimen retrieval safely and quickly without specimen damage and therefore may contribute to accurate pathological diagnosis. |
| Gastroenterology |
Cholangiocytes modulate CD100 expression in the liver and facilitate pathogenic Th17 differentiation. CD100 exerts its functional impact through cholangiocyte-immune cell crosstalk and underscores an active, proinflammatory role of cholangiocytes that can be relevant to novel treatment approaches. |
RET Signaling Persists in the Adult Intestine and Stimulates Motility by Limiting PYY Release from Enteroendocrine Cells. RET signaling normally limits nutrient-dependent peptide release from L-cells and this activity is necessary for normal intestinal motility in male mice. These effects could contribute to dysmotility in HSCR, which predominantly affects males, and uncovers a mechanism that could be targeted to treat post-prandial GI dysfunction. |
The Effect of Nationwide Organized Cancer Screening Programs on Gastric Cancer Mortality: a Synthetic Control Study. South Korea's nationwide GC screening has apparent benefits while the Japanese program's effectiveness is uncertain. The experiences of South Korea and Japan could serve as a reference for other countries. |
| Gastrointest Endosc |
Comparison of covered self-expandable metallic stents with 12-mm and 10-mm diameters for unresectable malignant distal biliary obstructions: A prospective randomized trial. The 12-mm covered self-expandable metallic stents provide a longer time to recurrent biliary obstruction than do 10-mm covered self-expandable metallic stents for managing unresectable malignant distal biliary obstruction. |
| Hepatology |
Base editing of the mutated TERT promoter inhibits liver tumor growth. These findings demonstrate that a sgRNA-guided CjABE efficiently converts the mutated TERT promoter -124 C>T to -124 C in HCC cells and underscore the potential to treat HCC by the base editing-mediated correction of TERT promoter mutations. |
PUS1 promotes hepatocellular carcinoma via mRNA pseudouridylation to enhance the translation of oncogenic mRNAs. Our study highlights the critical role of PUS1 and pseudouridylation in HCC development, and provides new insight that PUS1 enhances the protein levels of a set of oncogenes, including IRS1 and c-MYC, via pseudouridylation-mediated mRNA translation. |
| J Hepatol |
The adjusted prevalence of hepatitis delta virus (HDV) in 25 countries and territories. We found substantially lower HDV prevalence than previously reported, as prior meta-analyses primarily focused on studies conducted in groups/regions that have a higher probability of HBV infection tertiary care centers, specific risk groups or geographical regions. There is large uncertainty in HDV prevalence. The implementation of reflex testing would improve estimates, while also allowing earlier linkage to care for HDV-RNA-positive individuals. The logistical and economic burden of reflex testing on the health system would be limited, as it would only screen HBsAg+ cases. Impact and implications There is a great deal of uncertainty surrounding the prevalence of HDV among people living with HBV at the population level. This study aimed to better understand the burden in 25 countries and territories, to refine techniques that can be used in future analyses. We found a lower prevalence in the majority of places studied than had been previously reported. These data can help inform policy makers on the need to screen people living with HBV to find those coinfected with HDV and at high risk for progression, while also highlighting the pitfalls that other researchers have often fallen into. |
| J Neurogastroenterol Motil |
The Prevalence and Characteristics of Symptomatic Uncomplicated Diverticular Disease Among Asian Patients With Unexplained Abdominal Symptoms. It is important to recognize that patients with SUDD account for as high as 31% of outpatients with unexplained abdominal symptoms; these patients have diarrhea and a low QOL. The presence of right-sided SUDD was characteristic of Asian patients. |
Plenty of the editorials are available as full text through the publisher website using the provided link
| Clin Gastroenterol Hepatol |
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| Endosc Int Open |
| Gastroenterology |
| J Hepatol |
misc publications eg case reports, tools of the trade, images of the month, etc…
| Am J Gastroenterol |
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| Clin Gastroenterol Hepatol |
| Endosc Int Open |
| Endoscopy |
| Gastroenterology |
| Gastrointest Endosc |
| Hepatology |
| J Hepatol |
Letters to the editors and authors’ replies
| Clin Gastroenterol Hepatol |
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| J Hepatol |